Multifunctional Nanoplatform for Single NIR Laser-RegulatedEfffcient PDT/PTT/Chemotherapy

Abstract: The combination of phototherapy and chemotherapywith superior advantages is a promising strategy for cancer therapy.However, combination therapy is generally regulated by twodifferent wavelengths of light or other stimuli, which results incomplex operations and inevitable systemic side effects, evenaffecting therapeutic efffcacy. Herein, we design a signal NIR lightregulated nanoplatform via the self-assembly process of reactiveoxygen species (ROS)-sensitive prodrug (DTD), human serumalbumin (HSA), and IR780 for combined photothermal/photodynamic therapy and chemotherapy. Upon 808 nm laser irradiation,IR780 in nanoparticles generates abundant ROS and a signiffcantphotothermal effect to achieve photothermal/photodynamic therapy.Meanwhile, the generating ROS further cleans up the thioketal linkto release DOX for chemotherapy. Hence, signal NIR light can effectively control the process of combination therapy. In vivo and invitro experiment results demonstrate that the multifunctional nanoparticles exhibit excellent antitumor efffcacy via the combinationof phototherapy and chemotherapy controlled by a signal NIR laser. Overall, the signal NIR light-regulated nanoparticles withcombination therapy performance provide a versatile platform for enhancing antitumor efffcacy.

Yu Chen, Zhentan Lu, and Dong Wang. Multifunctional Nanoplatform for Single NIR Laser-RegulatedEfffcient PDT/PTT/Chemotherapy. A Biomacromolecules 2024, 25, 1038−1046.