Abstract：Full textile-based pressure sensors are gaining significant attention due to their high comfort and excellent adhesion to the body. However, their accuracy often diminishes under complex strains caused by body movements, such as stretching and bending, limiting their practical application. In this work, a programmatically fabricated strain-localizing yarn composed of periodically distributed conductive and mechanically adjustable coating layer was developed and integrated into a cross-intersecting configured textile-based deformation-adaptive pressure sensor (TDPS). This design leverages localized modulus differences to direct complex strain to specific areas, preventing intrinsic deformation of the sensing region and enabling deformation-adaptive and highly accurate pressure sensing. Under 30 % tensile strain and a curvature radius of 5 mm, the TDPS exhibited less than 8.1 % performance deviation, (approximately a 91 % reduction compared to conventional sensor configurations), while maintaining ultra-high sensitivity (531 N−1), fast response (150 ms), recovery (105 ms) and durability. The TDPS was seamlessly embroidered into a highly comfortable, full textile-based wristband and glove, demonstrating high-precision pulse monitoring and accurate grip force measurement. This innovation offers a promising pathway toward the development of comfortable, deformation-adaptive, and highly accurate wearable devices.