Nanofibrous membrane/thermoresponsive hydrogel composites with temperature-controlled capability for enhancing infected wounds healing

ABSTRACT: As a novel treatment, photothermal therapy (PTT) has been widely employed to deal with bacterial infection. Nevertheless, the high temperature in conventional PTT unavoidably results in damages to normal tissues. Herein, a nanofibrous membrane/thermoresponsive hydrogel composites (PB NCs@PLA/P(NIPAM-AM) hydrogels) with the ability to regulate heat generation are developed for the treatment of infected wound. Under NIR light laser irradiation, a large amount of heat generated by PB NCs@PLA nanofibrous membrane can be transferred to thermoresponsive P(NIPAM-AM) hydrogel. After reaching a lower critical solution temperature, P(NIPAM-AM) hydrogel rapidly undergoes phase transformation and generate considerable light-scattering centers to prevent NIR penetration. Through this dynamic and reversible process, temperature of PB NCs@PLA/P (NIPAM-AM) hydrogels can maintain at the predefined level to avoid overheating at the wound site. The PB NCs@PLA/P(NIPAM-AM) hydrogels not only exhibit excellent antibacterial effect, but also effectively protect normal tissues from damage, which improve the rate of wound closure. Therefore, the PB NCs@PLA/P(NIPAMAM) hydrogels provide a promising alternative for infected wound healing.

Journal of Colloid and Interface Science 680 (2025) 172–180